Kinetic UDR Immunoassay, enhanced with polystyrene particles, for their use on Beckman Coulter's IMMAGE® 800 Immunochemical Systems.

Applications available for the most common analyzers of Clinical Chemistry. For example Advia®, Alinity C, AU®, Atellica™, cobas® C, Optilite® or Mindray among others.

Clinical Significance of the Retinol Binding Protein (RBP) (serum and urine)

The values of RBP in plasma are elevated in type 2 Diabetes Mellitus, obesity, metabolic syndrome, cardiovascular disease and chronic kidney disease.

Decreased values due to proteinuria, hepatocellular carcinoma, hyperparathyroidism, cystic fibrosis or other causes, can pose a serious threat to transport of vitamin A to tissues.

In normal situation, the RBP filtered by the glomerulus is almost completely reabsorbed by the proximal renal tubules, where it is catabolized, and then only very little amount appears in the final excreted urine.

The elevation of urinary excretion of RBP is a good marker of tubular dysfunction due to any cause or pathology (transplants, diabetes, poisoning, etc.), because of its high sensitivity, stability and large dynamic range (a complete blockage of tubular reabsorption elevates the normal values by a factor of 10^4-10^5).

RBP, Diabetes Mellitus tipo 2, Tubular disfunction, Vitamin A, IMMAGE® Beckman Coulter, Optilite® The Binding Site, PENIA, TIA.